内皮素,心纳素与慢性肺心病发病关系的研究

目的 为了探讨内皮索、心钠素与肺心病的发病关系。方法 应用放射免疫分析法检测了30例肺心病患者和20例健康对照者动、静脉血浆中内皮素(ET)、心钠素(ANP)含量及PaO_2测定。结果 ①肺心病患者动、静脉血浆中ET、ANP含量均高于正常人。②肺心病患者动脉血浆中ET、ANP含量明显高于静脉血。③肺心病患者动、静脉血浆中ANP与ET含量呈现正相关关系。④肺心病患者动、静脉血浆中ET含量水平与PaO_2呈负相关关系。结论 ET、ANP及PaO_2测定有助于进一步探讨肺心病发病机理和提供辅助诊断依据。

A study on the endothelin and artrial natriuretic peptid in pathogenesis of pulmonary heart disease.

Objective To evaluate the level of Endothdlin (ET) and Artral Natriuretic Peptide(ANP) which related to pathogenesis of pulmonary heart disease. Methods The level of Arterial and Venous plasma ET and ANP was determined by Radio-immno assay (RIA) in 30 patients with pulmonary heart disease and 20 con-trolls. Results (l)The level of arterial and venous plasma ET and ANP was higher in patients with pulmonary heart disease than that in controlls. (2) In patients thelevel of arterial plasma ET and ANP was higher than that in venous one. (3)The level of arterial and venous plasma ANP was positively correlated with that of ET in patients. (4)The level of arterial and venous plasma ET was negatively correlated with arterial pressure of oxygen (PaO2) in patients. Conclusion Determing the level of ET and ANP could be helpful to study pathogenesis and diagnosis of pulmonary heart disease.