加替沙星与左氧氟沙星治疗泌尿系感染的Meta分析

目的 评价加替沙星与左氧氟沙星治疗泌尿系统感染的临床安全性、有效性，及疗效与成本。方法 检索1998年1月-2016年4月在PubMed、Cochrane图书馆、中国期刊全文数据库（CNKI）、万方数据库、中文科技期刊全文数据库（VIP）、中国生物医学文献数据库（CBM）发表的有关加替沙星与左氧氟沙星治疗泌尿系统感染的文献，按照Cochrane系统评价方法，运用Rev Man 4.2.10软件进行Meta分析。结果 纳入文献17篇，共1 348例；加替沙星治疗泌尿系统感染的有效性明显高于左氧氟沙星[RR=2.01，95% CI（1.44、2.79）]，疗程与不良反应无差异[RR=0.76，95% CI（0.50、1.17），P=0.22]，但加替沙星治疗泌尿系统感染的成本-效果明显低于左氧氟沙星。结论 目前泌尿系统感染的治疗方案中，尽管左氧氟沙星的疗效稍逊色于加替沙星，但左氧氟沙星更具成本-效果优势。

Meta-analysis of gatifloxacin and levofloxacin in treatment of urinary tract infection

Objective Evaluation of gatifloxacin and levofloxacin in the treatment of urinary tract infection clinical safety, effectiveness, efficiency, and cost of treatment. Methods Retrieving from January 1998 to April 2016 in PubMed, Cochrane Library, Chinese Journal Full-text Database (CNKI), Wanfang Database, Chinese Science and Technology Journal Full-text Database (VIP), Chinese Biomedical Literature Database (CBM) published on plus gatifloxacin and levofloxacin in the treatment of urinary tract infections in the literature, according to Cochrane systematic review methods, using Rev Man 4.2.10 Meta-analysis software. Results Document 17 included, a total of 1 348 cases; the effectiveness of gatifloxacin treatment of urinary tract infection was significantly higher than levofloxacin [RR=2.01, 95% CI (1.44, 2.79)], treatment and adverse indifference [RR=0.76, 95% CI (0.50, 1.17), P=0.22], but the cost of gatifloxacin treatment of urinary tract infection was significantly lower than the effect of levofloxacin. Conclusion Currently urinary tract infection treatment regimens, though the effectiveness of gatifloxacin was higher than levofloxacin, but levofloxacin more cost-effectiveness advantage.