HLA-DQA1、-DRB1等位基因与子宫内膜异位症和子宫腺肌病的比较性研究

目的 从免疫遗传学角度比较子宫内膜异位症和子宫腺肌症的异同。方法 采用顺序特异引物聚合酶链反应技术检测51例子宫内膜异位症和45例子宫腺肌病患者的HLA－DQA1和HLA－DRB1等位基因频率，并与44名正常人比较。结果 两患者组HLA－DQA1＊0301等位基因频率（8.8%,5.6%）均明显低于正常对照组，差异有显著性（Pc=0.00,Pc=0.00），而两患者组的HLA－DQA1＊0.0401等位基因频率（7.8％,10.0%）均明显高于对照组，差异有显著性（Pc=0.03,Pc=0.01）；两患者组之间HLA－DQA1、－DRB1各等位基因频率比较，差异无显著性。结论 子宫内膜异位症及子宫腺肌病均与HLA－DQA1＊0301、＊0401相关联，从HLA－DQA1、－DRB1角度分析，子宫内膜异位症与子宫腺肌病的发病机理可能有共同之处。

Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis

Objective To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis. Methods The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control. Results The frequencies of HLA-DQA1*0401(7.8%,10.0%) were significantly increased in the endometriosis group and the adenomyosis group ( Pc=0.03, Pc =0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups ( Pc=0.00,Pc =0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis. Conclusion The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.