原发性十二指肠腺癌的诊治现状

原发性十二指肠腺癌(PDA)是一种非常罕见的恶性肿瘤,早期起病隐匿,随病程进展可出现一些非特异性的临床表现。十二指肠气钡双重造影和十二指肠镜检查对诊断最有价值,确诊率分别为81.9%和89%。根治性手术是可获得治愈机会的唯一手段,术式选择取决于肿瘤的部位和分期。能否行根治性切除以及肿瘤的分期被认为是影响患者预后最显著的因素。近些年,随着影像学技术的进步和内镜的广泛应用,PDA的检出率逐年提高,该文拟就PDA的诊治现状作一简要综述。

Diagnosis and treatment of primary duodenal adenocarcinoma

Primary duodenal adenocarcinoma（PDA） is an exceedingly rare malignant tumour. It occurs silently and lacks specificity in clinical presentation in the early stage. When it develops to advanced stage,it ean presents the symptoms of epigastric pain, gastrointesti- nal bleeding, vomiting and jaundice. The most effective methods to diagnose are hypotonic duodenograghy and duodenoscope with the ac- curacy of 81.9% and 89% respectively. Definitive surgery is the only means of potential cure. The selection of operative type depends on the position and stage of tumor. The factors that have been found to significantly affect long-term survival are feasibility of radical resec- tion and the stage. In recent years,the development of endoscopic and radiologic diagnostic tests have increased the number of PDA diag- nosed. The present review summarizes the diagnosis and treatment of primary duodenal adenocarcinoma.