CGS 8216, a benzodiazepine antagonist, reduces food intake in food-deprived rats |
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| Authors: | P S Bernard G Pastor J M Liebman |
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| Affiliation: | 1. Genomic Sciences and Biotechnology Program, Catholic University of Brasilia, Brasilia, Brazil;2. Biosciences Research Institute, Athlone Institute of Technology, Athlone, Co. Westmeath, Ireland;3. Faculty of Medicine, University of Brasilia, Brasilia, Brazil;1. Durham University, Anthropology Department, Dawson Building, South Road, Durham, DH1 3LE, UK;2. Work conducted at the Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RZ, UK;1. Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia;2. Department of Medicine - Western Health, The University of Melbourne, Melbourne, VIC, Australia;3. The Australian Institute for Musculoskeletal Science, The University of Melbourne, Victoria University and Western Health, Melbourne, VIC, Australia;1. Department of Biophysics, Johns Hopkins University, Baltimore, Maryland;2. Physics Frontier Center (Center for Physics of Living Cells), University of Illinois, Urbana, Illinois;3. Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland;1. Department of Sociology and Demography, Population Studies and Population Aging Research Centers, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, 19104, USA;2. Department of Sociology and Sanford School of Public Policy, Duke University, Durham, NC, 27708, USA;3. Sanford School of Public Policy and Department of Sociology, Duke University, Durham, NC, 27708, USA |
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| Abstract: | CGS 8216, a benzodiazepine receptor antagonist with weak inverse agonist properties, reduced food intake in food-deprived rats when administered orally or intraperitoneally at doses that antagonize diazepam. This effect was sustained when CGS 8216 was administered daily for five days, indicating no rapid tolerance to the anorectic effect. Ro 15-1788 did not reduce feeding when administered orally, and was active only at high intraperitoneal doses (54 and 100 mg/kg). CGS 9896, a close analog of CGS 8216 but a benzodiazepine partial agonist with anxiolytic properties, did not reduce food intake at doses as high as 100 mg/kg IP or PO. These results support prior suggestions that benzodiazepine receptors may modulate feeding behavior, and suggest that CGS 8216 may have appetite suppressant properties. |
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