活性氧清除剂对实验性视神经炎作用的研究进展

活性氧簇(ROS)是神经系统脱髓鞘及血脑屏障破坏的媒介.ROS包括过氧化物及笑气(NO),由浸润的炎症细胞释放,其代谢产物包括过氧化氢(H202)、过(氧化)亚硝酸盐及羟基.在实验性视神经炎的动物模型中,发生了神经系统的脱髓鞘及血脑屏障的破坏,这和炎症细胞释放的ROS增加有密切关系,因此活性氧清除剂在保护炎症中的视神经免受氧化应激损伤方面显得尤为重要.本文针对近年来活性氧清除剂对实验性视神经炎的治疗研究作一综述,从而也从病因上对视神经炎的治疗进行探讨.

Progress of the therapy research of the active oxygen scavenger to experimental optic neuritis

Reactive oxygen species (ROS) are mediators of demyelination and disruption of the blood-brain barrier (BBB). Reactive oxygen species include superoxide and nitric oxide,released by infiltrating inflammatory cells,and their metabolites hydrogen peroxide (H2O2),peroxynitrite,and hydroxyl radical. Demyelination and disruption of the BBB occurs in nerve system of the experimental optic neuritis,which has great relationship with the release of the ROS by inflammatory cell. Thus the active oxygen scavenger plays an important role in the protection of the optic nerve in the inflammation from the injury of oxidative stress. The following article is a review of the therapy research of the active oxygen scavenger on experimental optic neuritis,thereby trys to find an active therapy of optic neuritis from the pathogenesis.