阿片类药物诱导机体氧化性损伤的研究进展

阿片类药物被广泛应用于镇痛、止咳、止泻、抗焦虑和催眠。阿片类药物在发挥其药理作用的同时 ,也会对机体产生多种毒性作用。其中对机体的氧化性损伤就是重要的毒性作用之一。一方面 ,阿片类药物可引起体内还原剂 (抗氧化剂 )谷胱甘肽浓度的下降 ,使机体容易受到氧化性损伤 ;另一方面 ,阿片类药物能够引起多种自由基浓度的升高 ,对机体多个器官和系统造成氧化性损伤。深入阐明阿片类药物诱导机体氧化性损伤的研究进展 ,对于阿片类药物的应用和滥用的防治具有积极的意义

Research progress in opioids induced oxidative injury

Opioids were widely applied to analgesia and treatment of coughing, diarrhea, anxiety and sleepless. Opioids had toxic effects while playing pharmaceutical roles with oxidative injury as one of the most important toxic effects. Multi-organ or systems in our body were more liable to be damaged either by opioids reduced concentration of glutathione, the reductant or antioxidant, or by increased concentration of reactive oxidative species. To further clarify the research progress in opioids induced oxidative injury is very important towards opioids applications as well as prevention and cure of drug abuse.