Autoimmunity against the ryanodine receptor in myasthenia gravis. |
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| Authors: | G O Skeie P K Lunde O M Sejersted A Mygland J A Aarli N E Gilhus |
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| Affiliation: | Department of Neurology, University of Bergen, Bergen, Norway. |
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| Abstract: | Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). A major antigen for these antibodies is the Ca2+ release channel of the sarcoplasmic reticulum the ryanodine receptor (RyR). These antibodies are found mainly in MG patients with a thymoma MG and correlate with severe MG symptoms. The antibodies recognize a region near the N-terminus on the RyR, which seems to be of importance for RyR regulation. The antibodies cause allosteric inhibition of RyR function in vitro, inhibiting Ca2+ release from sarcoplasmic reticulum. |
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