| 睫状神经营养因子对脊髓神经元的保护作用 |
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| 引用本文： | 许斌,李家顺,贾连顺,何成,吴宏.睫状神经营养因子对脊髓神经元的保护作用[J].第二军医大学学报,2000,21(5):409-411. |
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| 作者姓名： | 许斌 李家顺 贾连顺 何成 吴宏 |
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| 作者单位： | 1. 第二军医大学长征医院骨科,上海,200003
2. 第二军医大学基础医学部神经生物学教研室,上海,200003 |
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| 基金项目： | 国家自然科学基金资助项目!(39500044) |
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| 摘 要： | 目的：研究脊髓操作后脊髓神经元内酶学的变化，并探索睫状神经营养因子（ＣＮＴＦ）对神经元的保护作用，方法：用Ａｌｌｅｎ改良法打击摸型致ＳＤ大鼠Ｔ８脊髓操作分别于术前及术后３，７，１０ｄ测定脊髓组织内乙酰胆碱酯酶（ＡＣｈＥ）和酸性磷酸酶（ＡＣＰ）的含量。结果：ＡＣｈＥ于术后持续下降；ＡＣＰ在术后第３天开始上升，第７天至最高，以后逐渐下降；用ＣＮＴＦ处理的大鼠上述两种酶变化的幅度较小，且整个过程也比较平
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| 关 键 词： | 脊髓损伤 睫状神经营养因子 神经元 脊髓 |
| 修稿时间： | 】 |
Protective effect of ciliary neurotrophic factor on spinal neurons |
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| XU Bin,LI Jia-Shun,JIA Lian-Shun,HE Chen,WU Hong.Protective effect of ciliary neurotrophic factor on spinal neurons[J].Academic Journal of Second Military Medical University,2000,21(5):409-411. |
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| Authors: | XU Bin LI Jia-Shun JIA Lian-Shun HE Chen WU Hong |
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| Abstract: | Objective: To study the enzymic changes and protective effect of ciliary neurotrophic factor (CNTF) on neurons in spinal cord injury. Methods: SD rats were subjected to incomplete spinal cord injury with modified Allen methods. Activities of acetylcholinesterase (AChE) and acid phosphatase (ACP) in spinal cord were quantitatively measured preoperatively, and 3,7, 10 days after spinal cord injury. Results: AChE activity decreased gradually after injury. ACP activity increased 3 days after injury, and reached peak on the 7th day, then recovered gradually. The rats treated with CNTF showed relatively smooth change of the 2 kinds of enzymes. Conclusion: CNTF plays a role in protecting the spinal cord neurons against injury. |
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| Keywords: | spinal cord injuries ciliary neurotrophic factor neurons spinal |
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