Successful treatment with intravenous colistin for sinusitis, orbital cellulites, and pneumonia caused by multidrug-resistant metallo-beta-lactamase-producing Pseudomonas aeruginosa in a patient with acute myeloid leukemia |
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| Authors: | Takashi Saito Akifumi Takaori-Kondo Masaharu Tashima Kohei Yamashita Yoshitsugu Iinuma Shunji Takakura Miki Nagao Tatsuo Ichinohe Takayuki Ishikawa Takashi Uchiyama Satoshi Ichiyama |
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| Affiliation: | (1) Department of Clinical Laboratory Medicine, Kyoto University Hospital, 54 Kawahara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan;(2) Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan |
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| Abstract: | The incidence of multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing P. aeruginosa has increased worldwide. The treatment options are limited for infectious diseases caused by these two organisms. The use of colistin has been of recent interest in cases involving both types. We report the case of a 74-year-old man with acute myeloid leukemia who was successfully treated with intravenous colistin for maxillary sinusitis and orbital cellulites due to MBL-producing MDRPA during neutropenia, and then for pneumonia caused by the bacteria after the recovery of neutrophil counts. |
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| Keywords: | Colistin Metallo-beta-lactamase Pseudomonas aeruginosa Multidrug-resistance |
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