| T细胞亚群及其细胞因子在原发性肾小球病中的变化 |
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| 引用本文： | 王淑岩,施广霞,赵久阳,马悦.T细胞亚群及其细胞因子在原发性肾小球病中的变化[J].现代免疫学,2002,22(6):402-404. |
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| 作者姓名： | 王淑岩 施广霞 赵久阳 马悦 |
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| 作者单位： | 1. 大连医科大学附属第二临床医院肾内科,大连,116027
2. 大连医科大学病理生理学教研室,大连,116023 |
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| 摘 要： | 为观察不同病理类型原发性肾小球病患者的外周血中CD3、CD4和CD8三种T细胞亚群 ,及Th1和Th2所分泌的代表性细胞因子IL 4、IL 10和TNF α的变化 ,从而分别取原发性肾小球病患者的全血和血清 ,采用流式细胞技术测定T细胞亚群 ,ELISA法测定细胞因子IL 4、IL 10和TNF α。结果是原发性肾小球病组中CD3+ 、CD8+ 细胞比例增高 ,而不同类型的肾炎 ,T细胞亚群的变化不尽相同。微小病变型、系膜增生型和膜性肾病患者表现为IL 4增高 ,而IgA肾病患者则降低 ;四种不同的病理类型病人的IL 10均降低 ,尤以IgA肾病最明显。膜性肾病、微小病变型、系膜增生型肾炎患者Th2细胞功能增强 ;IgA肾病患者有Th1优势应答的可能 ;IL 10的水平明显降低可能是原发性肾小球病发生发展的重要机制之一
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| 关 键 词： | 原发性肾小球病 T细胞亚群 细胞因子 |
| 文章编号： | 1001-2478(2002)06-0402-03 |
| 修稿时间： | 2002年1月28日 |
Changes in the Levels of T Helper Cells and Their Cytokines in Primary Glomerular Disease |
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| WANG Shu-yan ,SHI Guang-xia ,ZHAO Jiu-yang ,MA Yue.Changes in the Levels of T Helper Cells and Their Cytokines in Primary Glomerular Disease[J].Current Immunology,2002,22(6):402-404. |
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| Authors: | WANG Shu-yan SHI Guang-xia ZHAO Jiu-yang MA Yue |
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| Institution: | WANG Shu-yan 1,SHI Guang-xia 2,ZHAO Jiu-yang 1,MA Yue 1 |
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| Abstract: | CD3 +,CD4 +,CD8 + and IL-4,IL-10,TNF-α were determined in order to study the disorder of T helper cells which played a critical role in the development of primary glomerular disease Results showed that the changes of T helper cells and their cytokines were not completely same in different patterns of primary glomerular diseaase The functional enhancement of Th2 cells was one of the important mechanisms for the development of mesangial proliferative glomerulonephritis,minimal change glomerulonephritis,and membranous glomerulonephritis It suggested that IgA nephropathy may participate the Th1 involvment Significant decrease in the level of IL-10 may play an important role in the development of primary glomerular disease - |
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| Keywords: | primary glomerular disease cytokine T helper cells |
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