通窍活血汤治疗缺血性脑卒中疗效及对患者血管性假血友病因子与血浆血栓调节蛋白水平的影响

目的：观察通窍活血汤对缺血性脑卒中患者血浆血管性假血友病因子（vWF）、血浆血栓调节蛋白水平（TM）的影响及疗效。方法：76例缺血性脑卒中的患者随机分为观察组和对照组各38例．两组患者均予以控制颅内压、抗血小板聚集、降脂及营养脑神经等治疗，观察纽在此基础上口服通窍活血汤，bid，连用4周。，观察治疗后两组患者的血清vWF、TM水平和脑卒中灶面积变化，比较两组临床疗效和安全性。结果：治疗4周后，两组患者血清vWF、TM和脑卒中灶面积水平均较前明显降低（P〈0．05和P〈0．01），观察组比对照组降低更明显（P〈0．05）；观察组11名床总有效率为89．47％，明显高于对照组（P〈0．05）；两组不良反应发生率比较，差异无统计学意义（P〉O．05）。结论：通窍活血汤治疗缺血性脑卒中疗效确切，安全性好，可降低患者的血清vWF和TM水平，具有保护和改善患者血管内皮功能作用。

Curative Effect of Tongqiao Huoxue Decoction on Von Wilebrand Factor and Thrombomodulin in Plasma of Patients with Cerebral Arterial Thrombosis

Objective：To observe the curative effect nf Tongqiao Huoxue decoction on Vou Wilebrand Factor （VWF） and Thrombomodulin （TM） in plasma of patients with cerebral arterial thrombosis. Methods ：76 eases of patients with cerebral arterial thrombosis were random divided into observation group anti control group at random. The patients in the two groups were given symptomatic treatments such as control of intracranlal pressure, platelet aggregation, lipid-lower- ing, nervi cerebrales nutrition after admitted to hospital. The patients in the observation group were given Tnngqiao Huoxuc decoction twice a day for 4 weeks. The changes af VWF and TM levels of patients anti stroke lesion volume in the lwn groups after the medical treatment were observed, and clinical curative effect anti security were t：ompared as well. Results： After 4 weeks＇ medical treatment, the serum VWF anti TM levels of the patients and stroke lesion volume in the two groups more obviously declined than before （P 〈0.05 and P 〈 O. 0f ） , and the declining rate in the observation group was much higher than that in the control group （P 〈 0.05 ）. The total clinical efficiency of the patients in the observation group （89.47%） was much higher than that in the control group （71.05%） （P 〈 0.05 ）. There was no statistical tlifferenee（ P 〉 0.05 ） in the occurrence rates of the untoward effect of the patients in the two groups. Conclusion： Tongqiao Hunxue decoction had its reliable curative effect on cerebral arterial thrombosis with high security, which could reduce the serum VWF and TM levels of patients and protect and improve the vascular endothelial function.