坎地沙坦酯预防高血压病并心房颤动复律后复发的临床研究

目的：探讨血管紧张素Ⅱ受体拮抗剂坎地沙坦酯预防高血压病并心房颤动复律后复发的效果。方法：将原发性高血压合并持续性或阵发性房颤经电转复或药物恢复窦性心律的78例患者随机分为观察组与对照组。两组恢复窦律后均选用胺碘酮维持窦律，观察组以坎地沙坦酯4—8mg／d，作为基础用药，对照组以氨氯地平5～10mg／d为基础用药，随访1年。观察两组患者1年内的房颤复发率，治疗前后做超声心动图测量左心房内径．观察两组血压控制水平。结果：观察组房颤复发率较对照组明显降低（P〈O．05）；治疗后观察组左心房内径较治疗前有明显下降（P〈O．05）；治疗后两组间左心房前后径比较差异有统计学意义（P〈O．05）；两组患者治疗后血压控制水平无显著性差异（P〉0．05）。结论：长期服用坎地沙坦酯可逆转高血压病并房颤引起的左心房扩大，减少房颤发作。

Clinical Study of Candesartan Cilexetil in Preventing Recurrence of Essential Hypertension Complicated with Atrial Fibrillation

Objective：To investigate the effect of candesartan cilexetil in preventing recurrence of essential hypertension complicated with atrial fibrillation （AF）. Methods： 78 patients with essential hypertension complicated with AF who were recovered the sinus rhythm through electrotherapy or medicines were randomly divided into observation group and control group. Aminodarone were used in all patients to keep the sinus rhythm. Candesartan cilexetil 4-8 mg/d was added in observation group,and Norvasc 5-10 mg/d was added in control group. The follow- up lasted one year. The recurrent rates of AF in two groups were observed during one year, the inner diameter of left atrium was measured by echocardiogram and the blood pressure was observed in two groups before and after treatment. Results： The recurrent rate of AF in observation group decreased significantly compared with that in control group （P〈0.05）. After treatment the inner diameter of left atrium in observation group decreased significantly compared with that before treatment（P〈0.05）. The inner diameter of left atrium after treatment showed significant difference between the two groups （P〈O.05）.After treatment there was no significant difference in the blood pressure between the two groups（P〉0.05）. Conclusions： Long term treatment of candesartan cilexetil may reverse the enlargement of Deft atrium of patients with essential hypertensior complicated with AF,and reduce the onsets of AF.