福建省闽南地区506例肾小球疾病临床与病理流行病学研究

目的　探讨闽南地区肾小球疾病的临床分型与病理改变之间流行病学意义。方法　全部病例均经皮肾活检。光镜 (HE ,PASPAM及Masson染色 )免疫组化 ,部分送电镜。结果　原发性肾小球肾炎 416例 (82 2 % ) ,病理以系膜增生(4 6 6 % ) ,IgA肾病 (2 2 1% )多见。继发性肾小球肾炎 90例中狼疮性肾炎 43例 (73 3 % ) ,病理以膜增殖为主 (5 2 3 % )。结论　系膜性病变仍占肾小球疾病首位 ,且无明显地区性差异。局灶节段性硬化有逐年增多趋势。狼疮性肾炎发病率低于北京地区。

Clinical and Pathological Epidemiologic Study of 506 Cases with Glomerular Disease in the South of Fujian

Objective To study whether there is epidemiologic significance in clinical classification and the pathological changes of glomerular disease in the south of Fujian. Method All cases were examined by using percutaneous renal biopsy, light microscopy (staining by HE, PASPAM and Masson), immunohisto chemical staining. Some were examined by electron microscopy. Result 416 cases (82.2%) were primary glomerulonephritis, whose pathology mostly constituted of mesangial proliferative glomerulonephritis (46.6%) and IgA nephropathy (22.1%). 90 cases (17.8%) were secondary glomerulonephritis, 43 cases of which were lupus nephritis, and their pathology was mostly membrahypertrophy (52.3%). Conclusion Mesangial pathological changes are in the first place of the glomerular diseases and have no regional difference; The incidence of local segmental glomerulosclerosis increases year by year; The incidence of lupus nephritis is lower than that in Beijing region