不同分子亚型乳腺癌3.0 T MRI影像表现分析

目的 探讨不同分子亚型乳腺癌MRI影像表现特征.材料与方法 回顾性分析潍坊市中医院经手术或穿刺病理证实的240例乳腺癌患者MRI影像表现,对比分析不同分子亚型乳腺癌患者肿瘤大小、形态、边界、强化方式、时间-信号强度曲线(time-signal intensity curve,TIC)类型、乳腺背景实质强化(backgr...

3.0 T MRI features of breast cancer in different molecular types

Objective:To explore the MRI features of breast cancer indifferent molecular types.Materials andMethods:MRI findings of 240 patients with breast cancer confirmed by operation or puncture pathology in our hospital were retrospectively analyzed.The MRI features of tumor size,shape,boundary,enhancement type,time signal intensity curve(TIC),background parenchymal enhancement(BPE),peritumoral edema,and presence of axillary enlarged lymph nodes were compared in different molecular subtypes of breast cancer.Statistical analysis was performed by chi square test of contingency table to analyze the MRI imaging features and correlation of breast cancer in different molecular types.Results:There were statistically significant differences in the size(C=0.197,P=0.021),shape(C=0.247,P=0.015),enhancement type(C=0.251,P=0.012),type of TIC(C=0.253,P=0.011),and incidence of axillary enlarged lymph nodes(C=0.189,P=0.029)among different molecular subtypes of breast cancer.Luminal A subtype often presented as a round mass lesion≤2 cm(70%).Luminal B subtype TIC curves were mostly typeⅢ(81.3%).HER-2 subtypeaccounted for a higher proportion of non-mass type breast cancer(41.7%),and had a high incidence of axillary enlarged lymph nodes(50%).Round mass lesion(84%)and ring enhancement(64%)were more often found in triple negative breast cancers(TNBC).Peritumoral edema was found in 52%of TNBC and 45.8%of HER-2 subtypes,that was significantly higher than luminal A(18%)and luminal B(25%)(P<0.01).There was no significant correlation between tumor boundary(C=0.195,P=0.141),BPE(C=0.158,P=0.720)and molecular subtypes.Conclusions:Different molecular subtypes of breast cancer have certain characteristics on MRI.According to the MRI features of breast cancer,the molecular classification can be preliminarily predicted,which will facilitate subsequent treatment planning and prognosis assessment.