急性心肌梗死溶栓治疗对血浆C—反应蛋白（CRP）水平的影响

目的：研究溶栓治疗对急性心肌梗死（AMI）患者血浆C－反应蛋白（CRP）水平的影响，方法：42例确诊的AMI患者，经静脉溶栓或一般治疗，测定入院时即刻和胸痛发作后2，4，6，10，14，24小时及第2至第9天的血浆CRP，CK－MB浓度。结果：（1）AMI患者血浆CRP与CK－MB水平呈正相关，（2）溶栓治疗成功者血浆CRP峰值水平明显下降（P＜0．05）。结论：溶栓治疗可明显降低AMI患者血浆CRP水平，这种降低可能与溶栓治疗减轻了急性炎症反应有关。

Effect of Thrombolytic Treatment on Serum C-Reactive Protein(CRP)in Acute Myocardial Infarction

Objective To study the effect of thrombolytic treatment on serum C-Reactive protein(CRP)in acute myocardial infarction(AMI).Methods 42 patients were accepted intravenous thrombolytic treatment or general treatment,determined their serum CRP and creatine kinase MB(CK-MB)concentrations at the time of admission and 2,4,6,10,14,20,24 hours and then daily from 2 to 9 days after the onset of chest pain.Results (1)There was a positive correlation between the serum CRP and CK-MB peak values in AMI.(2)Serum CRP peak levels decreased apparently in patients under successful thrombolytic treatment,compared with the patients in whom reperfusion failed or who received no thrombolytic treatment(P<0.05).Conclusion Successful thrombolytic treatment significantly reduced serum CRP levels in patients of AMI in this study,which may be related to the lightening of acute inflammatory reaction by successful reperfusion.