Cholecystokinin octapeptide-evoked [3H]acetylcholine release from guinea pig gallbladder |
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| Authors: | T Yamamura T Takahashi M Kusunoki M Kantoh Y Ishikawa J Utsunomiya |
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| Institution: | 1. Laboratório de Biologia Celular e Molecular, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Brazil;2. Cerlev — Projetos e Inovação na Biotecnologia da Fermentação Ltda, Rua Amaro Lanari 59, Saramenha, 35.400-000 Ouro Preto, MG, Brazil |
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| Abstract: | Cholecystokinin-octapeptide (CCK-OP) produced a contractile response in isolated guinea pig gallbladder; the response consisted of scopolamine-sensitive and scopolamine-insensitive components, neither of which were affected by tetrodotoxin or hexamethonium. In the presence of tetrodotoxin, CCK-OP evoked 3H]acetylcholine (ACh) release from strips of gallbladder in a concentration-dependent manner. These results suggest that CCK-OP acts at two sites in the guinea pig gallbladder, viz. the smooth muscle cell and the postganglionic cholinergic nerve terminal. |
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