Benzodiazepine receptor binding in Huntington's disease: [11C]flumazenil uptake measured using positron emission tomography |
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| Authors: | Künig G Leenders K L Sanchez-Pernaute R Antonini A Vontobel P Verhagen A Günther I |
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| Affiliation: | PSI, Paul Scherrer Institut, PET Program, Villigen, Switzerland. |
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| Abstract: | We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation. |
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