Kalirin研究进展 |
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引用本文: | 王玲琳,;李雪萍. Kalirin研究进展[J]. 西北医学教育, 2014, 0(3): 628-630 |
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作者姓名: | 王玲琳, 李雪萍 |
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作者单位: | [1]西安医学院 教务处,陕西西安710021; [2]西安医学院 研究生处,陕西西安710021 |
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基金项目: | 陕西省教育厅科学研究项目(12JK0752);西安医学院科研基金项目(2011DOC01) |
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摘 要: | Kalirin是新近发现的一种鸟苷酸交换因子,研究发现其具有神经保护作用。本文综述了Kalirin在常见的几种退行性神经病和精神障碍、雌激素相关疾病中的分子生物学研究进展,并对其基因表达水平改变进行了分析,提出了一些治疗这些疾病的新思路。
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关 键 词: | Kalirin 退行性神经病 精神障碍 |
Recent Research Progress of Kalirin in Neurodegenerative Diseases |
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Affiliation: | WANG Ling-lin, LI Xue-ping(1 Department of Teaching Affairs;2. Graduate Department, Xi' an Medical University, Xi' an 710021, China) |
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Abstract: | Kalirin is a newly discovered Rho guanine-nucleotide exchange factor,It is demonstrated as a neuronal protective factor for neurodegenerative diseases.This paper article reviewed the discovery, molecular structure,type,expression and the role of Kalirin in several neurodegenerative diseases, dysphrenia and the estrogen related diseases,focused on the alteration of gene expression level,and put forward some new ideas for the treatment of these diseases. |
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Keywords: | Kalirin neurodegenerative diseases dysphrenia |
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