| HPLC测定扎托洛芬片的含量及有关物质 |
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| 引用本文： | 汪涛,邓树海,徐丽洒,万发里. HPLC测定扎托洛芬片的含量及有关物质[J]. 中国药学杂志, 2007, 42(5): 389-390 |
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| 作者姓名： | 汪涛 邓树海 徐丽洒 万发里 |
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| 作者单位： | 1. 山东大学药学院,济南,250012
2. 青岛大学药学系,山东,青岛,266021 |
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| 摘 要： | 目的建立HPLC测定扎托洛芬片的含量及有关物质的方法。方法色谱柱为Diamonsil C18柱(4.6 mm×150 mm,5μm),流动相为乙腈-水-醋酐(60∶40∶0.5),检测波长332 nm。结果扎托洛芬在30～70 mg·L-1内线性关系良好(r=0.999 9),平均回收率为99.7%(RSD=0.74%)。结论本方法操作简单,分离效果好,灵敏度高,结果准确可靠。
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| 关 键 词： | 高效液相色谱法 扎托洛芬 含量测定 有关物质 |
| 文章编号： | 1001-2494（2007）05-0389-02 |
| 收稿时间： | 2006-05-10; |
| 修稿时间： | 2006-05-10 |
Determination of Zaltoprofen and Its Related Substances in Zaltoprofen Tabets by HPLC |
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| WANG Tao,DENG Shu-hai,XU Li-sa,WAN Fa-li. Determination of Zaltoprofen and Its Related Substances in Zaltoprofen Tabets by HPLC[J]. Chinese Pharmaceutical Journal, 2007, 42(5): 389-390 |
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| Authors: | WANG Tao DENG Shu-hai XU Li-sa WAN Fa-li |
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| Affiliation: | 1. School of Pharmacy, Shandong University, Jinan 250012, China ; 2. School of Pharmacy, Qingdao University, Qingdao 266021, China |
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| Abstract: | OBJECTIVE To establish a HPLC method for determining the content and related substances of zaltoprofen tablet.METHODS The analytical column was Diamonsil C18(4.6 mm×150 mm,5 μm).The mobile phase was acetonitrile-H2O-acetic anhydride(60∶40∶0.5).The flow rate was 1.0 mL·min-1,and the detective wavelength was 332 nm.RESULTS The standard curve of zaltoprofen was linear in the range of 30～70 mg·L-1(r=0.999 9);the average recovery was 99.7%(RSD=0.74%).CONCLUSION This method is simple,accurate and sensitive. |
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| Keywords: | HPLC zaltoprofen quantitative determination related substances |
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