Treatment of Caffeine Intoxication by Exchange Transfusion in a Newborn |
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Authors: | C. PERRIN D. DEBRUYNE J. LACOTTE D. LALOUM J.-B. BONTE M. MOULIN |
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Affiliation: | Division of Neonatology;Laboratory of Pharmacology, University Hospital Center, Caen, France |
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Abstract: | ABSTRACT. The symptoms of acute poisoning after accidental administration of ten times the usually prescribed dosage of caffeine in a premature infant included the following neurological signs: incessant tremors, hypertonia, continuous opisthotonos posture, whining and crying and digestive disturbances. The very high serum caffeine levels, 160 mg/l, determined 66 hours after the first administration was confirmed by the very high cerebrospinal fluid caffeine concentration 115 mg/l. Two exchange transfusions performed at an interval of 16 hours produced a large decrease in serum caffeine levels of approximately 40 mg/l each time, and a similar decrease in the cerebrospinal fluid concentration. The clinical status of the infant improved very rapidly and the child's psychomotor development was normal at 3 months of age. |
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Keywords: | caffeine intoxication newborn exchange transfusion serum levels |
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