Comparative in vitro activity of the new oral cephalosporin BMY-28100

Using a broth microdilution method, the in vitro activity of BMY-28100 against 365 clinical strains of commonly isolated bacteria was determined. BMY-28100 showed good activity against streptococci, methicillin-susceptible staphylococci,Salmonellaspp.,Shigellaspp., and beta-lactamase producingBranhamella catorrhalisandHaemophilus influenzae.Against susceptible strains of these organisms, BMY-28100 showed activity comparable to that of penicillin G, ampicillin, co-trimoxazole, erythromycin, cefaclor, doxycycline and amoxicillin/potassium clavulanate. BMY-28100 had moderate activity againstArizona hinshawiiand poor activity againstCampylobacter jejuniandYersinia enterocolitica.