不同~(131)I剂量对小鼠甲状腺吸~(131)I率和有效半衰期的影响

目的:探讨不同剂量的131I对甲状腺吸131I率及有效半衰期(Teff)的影响。方法:正常小鼠35只,分成7组,先测定示踪剂量的吸131I率和Teff,然后按每克甲状腺组织分别为30,60,70,80,90,100,170μCi给予治疗量131I,并测定治疗量的吸131I率和Teff。资料处理采用方差分析及q检验。结果:随着每克甲状腺组织131I用量增加,治疗量吸131I率呈下降趋势。170μCi组的吸131I率明显低于示踪剂量吸131I率(P<0.01),其他剂量组未获统计学差异。治疗量与示踪量131I和Teff之间没有显著性差异。结论:随着131I用量增加,治疗量吸131I率呈下降趋势,但131I剂量对Teff没有明显影响。

THE EFFECTS OF DIFFERENT DOSE RADIOIODINE ON ~(131)IUPTAKES AND EFFECTIVE HALF-LIFE OF MOUSE THYROIDndon

Objective: To investigate the effects of different dose radioiodine on both 131I uptake ratio and effective half-life of the mouse thyroid. Methods: Thirty-five mice were equally divided into seven groups, the 131I uptake ratio and effective half-life were determined in trace and therapeutic 131I dose. Each group is accepted 30,60,70、80,90,100,170 μCi 131I per gram thyroid respectively.The data were analyzed by Fisher test and q test. Results: With the 131I dose increase per gram thyroid, 131I uptake ratio showed decreasing trend,131I uptake ratio of the mice accepted 170 μCi 131I for per gram showed significant decrease compared with trace dose(P<0.01). However the therapeutic 131I dose showed no effect on the effective half-life compared with other dose groups. Conclusion: Following the use of 131I dose increasing per gram thyroid, uptake ratios with therapeutic dose shows decreasing trend, but the 131I dose has no effect on the effective half-life.