| Comparative analysis of postoperative outcomes of myasthenia gravis with and without thymoma |
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| 引用本文： | 王如文 林一丹 蒋耀光 薛志强 赵云平 马铮. Comparative analysis of postoperative outcomes of myasthenia gravis with and without thymoma[J]. 中国人民解放军军医大学学报, 2005, 20(5): 311-315 |
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| 作者姓名： | 王如文 林一丹 蒋耀光 薛志强 赵云平 马铮 |
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| 作者单位： | Department of Thoracic Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China |
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| 摘 要： | Objective： To explore the postoperative clinical characteristics and outcomes of myasthenia gravis with and without thymoma. Methods： Two hundred and forty-three patients with myasthenia gravis （MG） surgically treated in our department from 1978 to 2003 were studied retrospectively. The clinical characteristics, complication, remissions and survival rates were compared between MG with and without thymoma. Results： The patients of MG with thymoma were significantly older （P〈0.01）, had shorter duration of symptom （P〈0.01 ）, and higher myasthenia crisis rates after operation（P〈0.01 ） than those without thymoma. No difference of Osserman classification was found between the 2 groups. The complete remission rates and partial remission rates of MG with thymoma were significantly lower than those without thymoma at 1 and 3 years（P=0.049, P=0.000, P=0.015, P=0.010）, but no differences at 5 years（P=0.457, P=0.699）. The survival rates were lower inMG with thymoma than without thymoma （Log rank=18.58, P=0.000）. Conclusion： The clinical characteristics are different between MG with and without thymoma. The remission of symptom of MG with thymoma is worse than that of MG without thymoma in the near future, but similar in the long future. In a long-term, the death rate of MG with thymoma is significantly higher than that of MG without thymoma.
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| 关 键 词： | 肌无力 胸腺瘤 手术治疗 病理机制 |
| 收稿时间： | 2005-05-14 |
| 修稿时间： | 2005-07-11 |
Comparative analysis of postoperative outcomes of myasthenia gravis with and without thymoma |
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| Wang RuWen;Lin YiDan;Jiang YaoGuang;Xue ZhiJiang;Zhao YunPing;Ma Zheng. Comparative analysis of postoperative outcomes of myasthenia gravis with and without thymoma[J]. Journal of Medical Colleges of PLA(China), 2005, 20(5): 311-315 |
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| Authors: | Wang RuWen Lin YiDan Jiang YaoGuang Xue ZhiJiang Zhao YunPing Ma Zheng |
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| Abstract: | Objective: To explore the postoperative clinical characteristics and outcomes of myasthenia gravis with and without thymoma. Methods: Two hundred and forty-three patients with myasthenia gravis(MG) surgically treated in our department from 1978 to 2003 were studied retrospectively. The clinical characteristics, complication, remissions and survival rates were compared between MG with and without thymoma. Results: The patients of MG with thymoma were significantly older (P<0.01), had shorter duration of symptom(P<0.01), and higher myasthenia crisis rates after operation(P<0.01) than those without thymoma. No difference of Osserman classification was found between the 2 groups. The complete remission rates and partial remission rates of MG with thymoma were significantly lower than those without thymoma at 1 and 3 years(P=0.049, P=0.000, P=0.015, P=0.010), but no differences at 5 years(P=0.457, P=0.699). The survival rates were lower in MG with thymoma than without thymoma(Log rank=18.58,P=0.000). Conclusion: The clinical characteristics are different between MG with and without thymoma. The remission of symptom of MG with thymoma is worse than that of MG without thymoma in the near future, but similar in the long future. In a long-term, the death rate of MG with thymoma is significantly higher than that of MG without thymoma. |
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| Keywords: | thymoma myasthenia gravis thymectomy prognosis |
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