| β─内啡肽对正常人红细胞免疫功能的调控实验研究 |
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| 引用本文： | 孙志扬,过宗南,赵孟尧,岳志健,郭峰. β─内啡肽对正常人红细胞免疫功能的调控实验研究[J]. 现代免疫学, 1994, 0(4) |
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| 作者姓名： | 孙志扬 过宗南 赵孟尧 岳志健 郭峰 |
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| 作者单位： | 第二军医大学附属长海医院神经外科，第二军医大学长海医院免疫室 |
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| 摘 要： | 以健康人红细胞Ｃ３ｂ受体花环率为指标，观察不同浓度β─内啡肽对红细胞免疫功能影响。结果发现，低浓度时对红细胞免疫功能起促进作用，高浓度时则起抑制作用。加入一定浓度的纳洛酮后可以阻断β─内啡肽的作用，并对其机理及意义进行了讨论。
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| 关 键 词： | 红细胞免疫，β─内啡肽，纳洛酮 |
A LABORATORY STUDY ON THE EFFECT OF β─ENDORPHIN ON HEALTHY RBC IMMUNE FUNCTION |
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| Sun Zhiyang ,Gou Zhongnan ,Zhao Mengyao, Yue Zhijian. A LABORATORY STUDY ON THE EFFECT OF β─ENDORPHIN ON HEALTHY RBC IMMUNE FUNCTION[J]. Current Immunology, 1994, 0(4) |
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| Authors: | Sun Zhiyang Gou Zhongnan Zhao Mengyao Yue Zhijian |
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| Abstract: | To investigate the role of β─endorphin in the regulation of RBC immune function,the effect of β─endorphin on healthy RBC c3b receptor rosette-forming rate(RC3bRR) was studied in vitro. It was found that Pendorphin at 10￣(-6)～10￣(-5)mol/L could depress RC3bRR,while at 10￣(-8)～10￣(-7) mol/L could enhance RC3bRR. The regulating effect of β-endor phin on RC3bRR was blocked by naloxone. Our results indicated that β-endorphin could regulate RBC immune function and this action may be mediated by opioid receptor. |
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| Keywords: | β─Endorphin RBC immune function Naloxone |
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