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Xenotransplantation: past achievements and future promise
Authors:Dwyer Karen M  Cowan Peter J  d'Apice Anthony J F
Affiliation:Immunology Research Centre, St Vincent's Hospital, Melbourne, Victoria, Australia.
Abstract:Xenotransplantation offers a potential solution to the shortfall in donor organs for human transplantation. This review describes the barriers to xenotransplantation and the progress that has been made towards making it a clinical reality. Data from preclinical pig-to-primate cardiac and pulmonary xenografts are highlighted.
Keywords:Author Keywords: acute vascular rejection   complement regulatory proteins   galactose α  1   3 galactose (α  Gal)   Gal-knockout   hyperacute rejection   xenotransplantation
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