| 依巴斯汀口服溶液的制备及质量控制 |
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| 引用本文： | 谢丽晓,吴明钗,胡瑞颖,叶可人,林洁,金丽敏,陈晓孩.依巴斯汀口服溶液的制备及质量控制[J].海峡药学,2010,22(4):53-54. |
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| 作者姓名： | 谢丽晓 吴明钗 胡瑞颖 叶可人 林洁 金丽敏 陈晓孩 |
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| 作者单位： | 温州医学院附属第三医院,瑞安,325200 |
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| 摘 要： | 目的制备依巴斯汀口服溶液并建立其质量控制方法。方法以依巴斯汀为主药，8-环糊精为辅料制备口服溶液。采用高效液相色谱法测定依巴斯汀的含量。结果依巴斯汀在10～100mg·L^-1。范围内线性关系良好（r=0．9998）。平均回收率为98．99％（RSD=1．06％，n=3）。结论该口服溶液制备简单且质量可控。
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| 关 键 词： | 依巴斯汀 口服溶液 制备 质量控制 |
Preparation and quality control of ebastine oral solution |
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| XIE Li-xiao,WU Ming-chai,HU Rui-ying,YE Ke-ren,LIN Jie,JIN Li-min,CHEN Xiao-hai.Preparation and quality control of ebastine oral solution[J].Strait Pharmaceutical Journal,2010,22(4):53-54. |
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| Authors: | XIE Li-xiao WU Ming-chai HU Rui-ying YE Ke-ren LIN Jie JIN Li-min CHEN Xiao-hai |
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| Institution: | (The Third Affiliated Hospital of Wenzhou Medical College; Zhejiang Rui＇ an 325200, China) |
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| Abstract: | OBJECTIVE To prepare ebastine oral solution and establish a method tor its quality control. METHODS Ebastine and β-cyclodetrin were used as main compositions. The content of ebastine was determined by HPLC spectrophotometry. RESULTS The linear range of ebastine was 10-100 mg·L^-1（r = 0. 9998）, and the average recovery was 98.99 % （ RSD = 1.06 %, n = 3）. CONCLUSION The preparation of ebastine oral solution is simple, and the quality can be controlled. |
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| Keywords: | ebastine oral solution preparation quality control |
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