| 尖吻蝮蛇毒去纤酶对大鼠实验性DIC的影响 |
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| 引用本文： | 李麟仙,赵卫东,李树清,赵文洁,张晓菲. 尖吻蝮蛇毒去纤酶对大鼠实验性DIC的影响[J]. 中国药理学通报, 1988, 0(1) |
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| 作者姓名： | 李麟仙 赵卫东 李树清 赵文洁 张晓菲 |
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| 作者单位： | 昆明医学病理生理教研究，昆明医学病理生理教研究，昆明医学病理生理教研究，昆明医学病理生理教研究，昆明医学病理生理教研究 常州卫校 |
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| 摘 要： | 本文用凝血酶及PAMBA诱发大鼠弥漫性血管内凝血模型.iv去纤维酶后2h,肾小球微血栓形成率从对照组的59％下降为26％(P<0.01);血小板数减少明显,给药组(7.94±1.17)与对照组(3.1±1.4O)相比差异有高度显著性(P
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| 关 键 词： | 弥漫性血管内凝血 去纤酶 |
INFLUENCE OF DEFIBRINOGENASE ON EXPERIMENTAL DISSEMINATED INTRAVASCULAR COAGULATION ( DIC) IN RATS |
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| Li Linxian,Zhao Weidong,, Li Shuqing et al. INFLUENCE OF DEFIBRINOGENASE ON EXPERIMENTAL DISSEMINATED INTRAVASCULAR COAGULATION ( DIC) IN RATS[J]. Chinese Pharmacological Bulletin, 1988, 0(1) |
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| Authors: | Li Linxian Zhao Weidong & Li Shuqing et al |
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| Abstract: | Experimental DIC model was performed by infusion of thrombin and PAMBA. The rate of glomerular microthrombosis was declined from 56% of the control group to 26% of the treated 2h after venous injection of defibrinogenase. The reduction of pletelet count of the treated group (7.9 ±1.17) was more less than the control ( 3.1± 1.44). There was a trece content in plasma fibrinogen 1h after giv ing drug.It was a significant difference bet-ween the treated and control group (P<0.01). These results suggest that defibrinogenase has inhi bitory effects on experimental DIC in rats. |
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| Keywords: | Disseminated intravascular coagulation Defibrinogen ase |
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