Intrathecal administration of etoposide in the treatment of malignant meningitis: feasibility and pharmacokinetic data |
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| Authors: | Ate van der Gaast Pieter Sonneveld Dennis R. A. Mans Ted A. W. Splinter |
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| Affiliation: | (1) Department of Hematology, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands;(2) Department of Oncology, Free University Hospital, Amsterdam, The Netherlands;(3) Department of Medical Oncology, University Hospital Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands |
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| Abstract: | Summary Two patients presenting with malignant meningitis resulting from small-cell carcinoma of the lung and with lymphoblastic leukemia, respectively, were treated by intrathecal administration of etoposide. In both cases, this treatment was well tolerated and produced relief of the central nervous system symptoms. Pharmacokinetic data showed that cerebrospinal fluid drug levels of up to 5.2  g/ml were achieved, which were considerably higher than those obtained after i.v. administration of high-dose etoposide. |
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