重型肝炎与活动性肝硬化患者医院感染预后因素分析

目的:探讨影响重型肝炎、活动性肝硬化患者医院感染预后的危险因素及其防治措施。方法:前瞻性调查1996年4月至2000年12月住院的重型肝炎、活动性肝硬化患者医院感染情况并进行统计分析。结果:重型肝炎、活动性肝硬化医院感染病死率为37.36％(34/91),单因素分析表明血清胆红素、PT、补体C_3、血清胆固醇、血钠、白细胞总数、中性粒细胞比例、感染类型、并发症种类、侵袭性探作与预后有相关性,多因素分析表明低补体C_3及低胆固醇预后严重不良。结论:医院感染是导致重型肝炎、活动性肝硬化死亡的重要因素,血清低补体C_3及低胆固醇是影响预后的高危因素。

Multivariate Analysis of Prognostic Factors of Nosocomial Infection in Severe liver Diseases

Objective: In order to explore and control the prognostic factors of nosocomial infection in severe hepatitis and liver cirrhosis. Methods: A prospective study of nosocomial infection of severe hepatitis and liver cirrhosis was made in our hospital from April, 1996 to December,. 2000. To investigate the prognostic factors of nosocomial infection in severe liver diseases used logistic regression. Results : The fatality of nosocomial infection in severe liver diseases were 37. 36% (34/91). Multiple regression analysis selected the following variables significantly associated with nosocomial infection of severe liver diseases: serum bilirubin, prothrombin time, complement C3, serum cholesterol, serum sodium, white blood cells count,polymorphonuclear cell ratio,the kinds of nosocomial infection,severe complications and improper medical manipulations. The prognostic factors high correlated with nosocomial infection analysis by logistic analysis were : low serum complement C3 and cholesterol. Conclusion: The nosocomial infetion are important factors that cause high fatality in severe liver diseases. The prognostic factors high related with nosocomial infeation of severe liver diseases are low serum complement C3 and cholesterol level.