Relationship between hemoglobin affinity for oxygen and lipid peroxidation in fever

Hemoglobin affinity for oxygen (P₅₀ parameter) and the content of malonic dialdehyde (MDA), Schiff's bases, and diene conjugates in the plasma and red cell mass were examined in mixed venous blood of rabbits with pyrogenal fever. Correlation regression analysis of the tested parameters showed that reduction of the actual affinity of hemoglobin for oxygen is conducive to activation of free-radical processes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 7, pp. 27–30, July, 1994 Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences