| 乌司他丁对创伤后应激性肝损害的保护作用 |
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| 引用本文： | 王全楚,程正祥,邓应彪. 乌司他丁对创伤后应激性肝损害的保护作用[J]. 胃肠病学和肝病学杂志, 2010, 19(2) |
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| 作者姓名： | 王全楚 程正祥 邓应彪 |
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| 作者单位： | 解放军第153医院传染科,河南,郑州,450042 |
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| 摘 要： | 目的 探讨乌司他丁对各种创伤后应激性肝损害的保护作用.方法 观察71例各类创伤后应激性肝损害患者应用乌司他丁治疗前后患者血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(SB)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶活性(GSH-PX)和血浆内毒素(脂多糖,LPS)水平的变化.结果 经乌司他丁治疗后,患者血ALT、AST、SB、LPS和MDA均明显下降,血清SOD和GSH-PX则明显增加且在1周内快速恢复(P<0.05).结论 乌司他丁对创伤后应激性肝损害的保护作用可能与调节氧化应激因子、抑制内毒素血症有关.
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| 关 键 词： | 乌司他丁 创伤后应激性肝损害 氧化应激 内毒素 |
The protective effect of ulinastatin on hepatic stress injury after trauma |
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| WANG Quanchu,CHENG Zhengxiang,DENG Yingbiao. The protective effect of ulinastatin on hepatic stress injury after trauma[J]. Chinese Journal of Gastroenterology and Hepatology, 2010, 19(2) |
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| Authors: | WANG Quanchu CHENG Zhengxiang DENG Yingbiao |
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| Affiliation: | WANG Quanchu,CHENG Zhengxiang,DENG Yingbiao Department of Infectious Diseases,153th Hospital of PLA,Zhengzhou 450042,China |
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| Abstract: | Objective To study the protective effect of ulinastatin (UIT) on hepatic stress injury after trauma.Methods The contents of serum ALT,AST and SB,glutathione perioxidase (GSH-Px),malondialehyde (MDA),superoxide dismutase (SOD) and lipopolysaccharide (LPS) on 71 hepatic stress injury patients after trauma were determined before and after treated with UTI.Results ALT,AST,SB,LPS and MDA contents were significantly lower,and levels of SOD and GSH-Px were higher after ulinastatin 7 days treatment than before.Conc... |
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| Keywords: | Ulinastatin Hepatic stress injury after trauma Oxidative stress Lipopolysaccharide |
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