左归丸合解郁丸治疗围绝经期妇女抑郁症45例

目的:探讨左归丸合解郁丸治疗围绝经期妇女抑郁症的临床疗效及作用机制.方法:90例患者随机分为治疗组和对照组各45例.对照组采用盐酸度洛西汀20 mg,tid,口服;治疗组,左归丸,口服,9g/次,2次/d;解郁丸,口服,4 g/次,3次/d.疗程8周.评价汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数量表(PSQI),检测血清雌二醇(E2)、促卵泡成熟素(FSH)、促黄体生成素(LH)及血清5-羟色胺(5-HT).结果:治疗8周后治疗组HAMD及PSQI评分均低于对照组(P＜0.01);治疗组E2水平明显升高,高于对照组(P＜0.01);两组FSH,LH水平明显降低,治疗组FSH,LH水平低于对照组(P＜0.05,P＜0.01);两组血清5-HT水平明显升高,治疗组升高幅度不如对照组(P＜0.05);治疗组总有效率91.11％,优于对照组的75.55％ (P ＜0.05).结论:左归丸合解郁丸治疗围绝经期妇女抑郁症有较好的临床疗效,安全性好.

Zuogui Wan and Anti-despression Wan for Treating 45 Cases Menopausal Women with Depression

Objective:To study the clinical efficacy and mechanism of action for treating menopausal women with depression by Zuogui wan and anti-depression wan. Method:Ninety patients were randomly divided into treatment and control groups (n=45 each). Control group were treated with duloxetine 20 mg, tid, orally. The treatment group was given Zuogui wan, 9 g, bid orally and anti-depression wan, 4 g, tid, orally, for 8 weeks. The Hamilton Depression Rating Scale (HAMD), the Pittsburgh Sleep Quality Index Scale (PSQI), serum estradiol (E₂), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and serum 5-hydroxy tryptamine(5-HT) were used to evaluate the efficacy. Result:After 8 weeks treatment, HAMD and PSQI scores in the treatment group were lowered compared with those in the control group (P<0.01). In the treatment group, level of E₂ was significantly increased, higher than that in the control group (P<0.01). FSH and LH levels in the two groups were significantly lowered. The levels of FSH and LH were significantly lowered in the treatment group compared with those in the control group (P<0.05, P<0.01). Serum 5-HT levels were significantly elevated in the two groups, the level in treatment group was not increased as that much as in the control group (P<0.05). The total effective rate of treatment group(91.11%) was better than that in the control group(75.55%) (P<0.05). Conclusion:Zuogui wan and anti-depression wan are effective and safety for treating menopausal women with depression.