急性颅脑损伤患者血清BNP和NSE含量的变化及临床意义

目的：探讨急性脑损伤患者血清脑钠肽（BNP）和神经元特异性烯醇化酶（NSE）含量的变化及其机理和临床意义。方法：采用放射免疫分析对134例急性颅脑损伤患者和40例健康对照者血清BNP和NSE进行测定,并对结果进行统计学分析。结果：颅脑损伤后血清BNP含量显著低于正常对照组,且伤情越重,BNP浓度越低;NSE含量的变化正好与之相反,且两者之间存在明显的负相关（r=-0.674,P〈0.01）。结论：血清BNP和NSE有助于估计急性颅脑损伤患者病情轻重及预后。

Clinical Significance of Changes of Serum BNP and NSE Levels in Patients with Acute Craniocerebral Injury

Objective In study the clinical significance of changes of serum brain natriuritic peptide （BNP） and neuron specific cnolase （NSE） levels in patients with acute cranioccrebral injury （ACI）. Methods Serum BNP and NSE contents were determined with radioimmunoassay （RIA） in 134 patients with acute craniocerebral injury and 40 controls. Results The serum BNP level in the patients with ACI were significantly lower in the patients than those in controls and were much lower in severe cases. On the contrary, the serum NSE levels were significantly higher in the patients and there was a significantly negative correlation with BNP levels （ r = - 0. 674, P 〈 0.01 ）. Conclusion The results suggested that a close relationship existed between serum BNP, NSE levels and the severity of craniocerebral injury. Determinnation of serum BNP and NSE levels was helpful for asscssment of the disease process and out-come prediction.