子宫内膜异位症患者腹腔液白介素13浓度与异位内膜种植关系的研究

目的　探讨腹腔液白细胞介素 - 13与子宫内膜异位症发病机制的相关性。方法　收集近一年子宫内膜异位症和良性卵巢肿瘤患者腹腔液 ,采用双抗体夹心酶联免疫吸附法 (ELISA)测定IL - 13浓度。结果　内膜异位症腹腔液中IL- 13的浓度明显低于对照组腹腔液中浓度。两组间比较P <0 .0 1,具有显著性差异。结论　内膜异位症腹腔液中IL - 13的浓度降低 ,对巨噬细胞抑制作用降低 ,可能与内异症免疫发病机制有关。

Study on association between interleukin - 13 in the peritoneal fluid of patients with endometriosis and endometrium implantation

Objective: to investigate the relationship interleukin-13 in theperitoneal fluid with the pathophysiology of endometriosis Metheds:The levels of IL-13 were measured by using enzyme-linked immunosorbent assay(ELISA) in the peritoneal fluid of 20 patients with endometriosis(studygroup) and 20 patients with benign ovarian tumor(control group). Results: It was found that women with endometriosis had significantly lower amounts of IL-13 in peritoneal fluid compared with women without endometriosis(P<0.01). Canclusion: The reduced amounts of IL-13 in the peritoneal fluid of women with endometriosis may lead to a lack of suppression of macrophage activation,thereby contributing to the verall pathogenesis of this disease.