咪唑斯汀治疗慢性荨麻疹最佳服药时间初探

目的探讨咪唑斯汀治疗皮损发生无明显时间规律的慢性荨麻疹的最佳服药时间。方法将217例慢性荨麻疹患者随机分为两组(A组和B组),A组114例患者予每天早上8点口服咪唑斯汀10 mg,B组103例患者予每晚8点口服咪唑斯汀10 mg,分别于服药7天、14天后观察比较两组患者临床症状评分变化、疗效及不良反应。结果A组、B组口服咪唑斯汀治疗7天及14天与治疗前临床症状、体征评分差异有显著性;口服咪唑斯汀治疗7天A组和B组的临床有效率分别为8 5.0 9%和7 1.8 4%,差异有显著性(P<0.0 5);治疗1 4天A组和B组的临床有效率分别9 0.3 5%及78.64%,差异有显著性(P<0.05)。结论皮损发作无明显时间规律的慢性荨麻疹患者,每天早上8点口服咪唑斯汀10mg较每晚8点疗效好,且无明显不良反应。2周疗法较1周疗法的有效率明显高。

The Study of the Optimum Treatment Time of Chronic Urticaria with Mizolastine

Objective To investigate the optimum treatment time of chronic urticaria with mizolastine.Methods A randomized,controlled clinical trial was conducted.217 Patients with chronic urticaria were divided in two groups(Group A and Group B),114 patients in Group A were treated with mizolastine 10 mg at 8:00 am,meanwhile,103 patients in Group B were treated with mizolastine 10mg at 8:00 pm.All patients was followed up for fourteen days.Results A total of 214 patients with chronic urticaria were enrolled and finished the study.The efficacy of treating with mizolastine 10 mg for 7days and 14 days were higher in Group A(85.09%;90.35%) than that in Group B(71.84%;78.64%).Adverse reactions occured rarely and slightly in both groups,which included stomach uucomfortable,thirsty,tired,somnolence.Conclusion The efficacy in patients treated with mizolastine at 8:00 am is higher and more safety than that at 8:00 pm.