促红细胞生成素治疗重度新生儿缺氧缺血性脑病20例

目的观察促红细胞生成素对重度新生儿缺氧缺血性脑病的治疗效果。方法采用促红细胞生成素治疗重度新生儿缺氧缺血性脑病20例,同时设对照组20例,两组均给予＂三项支持、三项对症＂等常规治疗。观察治疗前后两组患儿临床神经症状和体征恢复时间、脑CT改变、新生儿行为神经测定（NBNA）评分并评价疗效。结果治疗组经治疗后神经症状和体征恢复时间、脑CT改变、NBNA评分均明显优于对照组,各项指标经统计学处理,差异有统计学意义（P〈0.05）。结论促红细胞生成素治疗重度新生儿缺氧缺血性脑病有明显疗效,临床可推广应用。

Curative Effect of Erythropoietin on Treating Severe Neonatal Hypoxic Ischemic Encephalopathy in 20 Cases

Objective To observe the curative effect of erythropoietin on treating neonatal hypoxic ischemic encephalopathy （HIE）. Methods 20 cases of HIE were treated by erythropoietin, at the same time the other 20 cases were as the control group. The two groups were given the conventional therapy such as three items of supports and three items of symptomatic treatments. The recovering time of clinical neuro- logical symptoms and signs, NBNA scores and brain CT changes were observed before and after treatment. The curative effects were evaluated on the two groups. Results The recovery time of clinical neurological symptoms and signs, CT changes and NBNA scores in the treatment group were obviously superior to those in the control group with statistical difference （P 〈 0. 05）. Conclusion Using erythropoietin to cure severe HIE has the obviously curative effect indeed and can promote the use of clinic.