| 心宁有效部位群抗心肌缺血缺氧处方优选 |
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| 引用本文： | 王宇红,蔡光先. 心宁有效部位群抗心肌缺血缺氧处方优选[J]. 世界中西医结合杂志, 2007, 2(3): 141-144 |
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| 作者姓名： | 王宇红 蔡光先 |
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| 作者单位： | 湖南省中医药研究院,湖南,长沙,410013;湖南中医药大学第一附属医院,湖南,长沙,410000;湖南省中医药研究院,湖南,长沙,410013 |
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| 基金项目： | 湖南科学技术厅资助项目 |
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| 摘 要： | 目的：优选抗心肌缺血药心宁有效部位群配比与剂量,确定心宁处方组成。方法：以抗心肌缺血与耐缺氧作用为考察指标,采用正交试验设计进行方剂学配伍研究。结果：丹参提取物与B草SFE萃取物配伍后,与模型组比较,抗心肌缺血与耐缺氧作用具有显著性差异（P〈0.05）。极差大小与方差分析结果表明,丹参提取物抗心肌缺血作用优于B草萃取物,B草萃取物耐缺氧作用大于丹参提取物。结论：丹参提取物（A）与B草SFE萃取物（B）的最佳配伍比例为A3B2,心宁最优日服用剂量为低剂量（0.8g）。
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| 关 键 词： | 心宁有效部位群 正交试验 处方优选 |
| 文章编号： | 1673-6613(2007)03-0141-04 |
| 修稿时间： | 2006-12-15 |
Formulation Research of Xinning by Optimizing its Effective Location Group against Cardiac Ischemia and Hypoxia |
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| Wang Yuhong,Cai Guangxian. Formulation Research of Xinning by Optimizing its Effective Location Group against Cardiac Ischemia and Hypoxia[J]. World Journal Of Integrated Traditional and Wesrern Medicine, 2007, 2(3): 141-144 |
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| Authors: | Wang Yuhong Cai Guangxian |
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| Affiliation: | Wang Yuhong, Cai Guangxian ( 1. Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410013, China ;2. 1st Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410000, China) |
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| Abstract: | Objective:To optimize the effective part group and dose of Xinning to against cardiac ischemia, in order to determine the composition of the formula. Methods: Take the anti-ischemia anti-hypooxia as the investigation index, study the combination of the formula with a orthogonal experiment design. Results: The combination of the extractant of Salvia miltiorrhiza and the SFE extractant of Herb B is more effective in anti-ischemia and anti-hypoxia (P<0.05). It was showed in range and variance analysis that the extractant of Salvia miltiorrhiza is more powerful than that of the Herb B in anti-ischemia, however, the hypoxia-standing capacity of the Herb B is high than Salvia miltiorrhiza. Conclusion: The best compatibility proportion between the extractive of Salvia miltiorrhiza (A) and the extractant of the Herb B is A3B2, and the best daily dose is low dosage(0.8 g). |
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| Keywords: | Effective part group of Xinning Variance analysis Formula optimizing |
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