NIDDM病人红细胞变形能力与红细胞ATP酶活性和红细胞内离子浓度关系的研究

本文检测了４２例ＮＩＤＤＭ病人红细胞变形能力（ＥＤ）和红细胞ＡＴＰ酶活性、红细胞内离子浓度的变化。结果显示ＮＩＤＤＭ病人红细胞滤过指数（ＩＦ）较对照组明显增高（Ｐ＜０．００１）；红细胞Ｎａ＋－Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性较对照组明显降低（Ｐ＜０．０１），Ｍｇ２＋－ＡＴＰ酶活性变化不明显；红细胞内Ｎａ＋、Ｃａ２＋浓度较对照组明显增高（Ｐ＜０．０１），而Ｍｇ２＋浓度较对照组明显降低（Ｐ＜０．０１）。有血管病变者这些变化较无血管病变者更明显。ＮＩＤＤＭ病人红细胞ＩＦ与Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－ＡＴＰ酶活性呈负相关（ｒ＝－０．４６８，－０．４５８，Ｐ＜０．００１），与红细胞内Ｎａ＋、Ｃａ２＋浓度呈正相关（ｒ＝－０．４７３，０．４６６，Ｐ＜０．Ｄ０１），与Ｍｇ２＋浓度呈负相关（ｒ＝－０．４３６，Ｐ＜０．０１）。

A study on the relationship between the erythrocyte deformability and the activities of erythrocyte ATP-ase and the concentrations of intraerythrocytic ions in NIDDM patients

The erythrocyte deformability (ED), erythrocyte ATPase activities and intraerythrocytic ionic concentrations were determined in 42 NIDDM patients. The erythrocyte filtration index (IF)in patients with NIDDM was significantly higher than in normals (P<0.001).Na -K -ATPase,Ca2 ATPase activities were significantly lower than in normals (P<0.01),and there was no difference in Mg2 ATPase activity between the two groups. Intraerythrocytic Na , Ca2 concentrations were significantly higher and Mg2 concentration was significantly lower in patients with NIDDM than in normals (P<0.01).These abnormalities of ATPase and ionic levels in patients with angiopathies were more obvious than those of patients without.Erythrocyte IF was negatively correlated with Na -K -ATPase and Ca2 -ATPase activity.There was positive correlation between IF and Na ,Ca2 concentration,and IF was negatively correlated with Mg2 concentration.