Generation of free oxygen radicals and clastogenesis in bone marrow cells in MRL/1 mice |
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| Authors: | N. V. Guseva A. D. Durnev G. N. Pleskovskaya T. A. Lisitsina S. B. Seredenin V. A. Nasonova |
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| Affiliation: | (1) Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow;(2) Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | The level of chemiluminescence induced by phorbol myristate acetate or opsonized zymosan in the bone marrow cells of 5–6-month-old male MRL/1 mice is significantly higher than that in the same cells of 1–2-month-old mice. The number of chromosome aberrations induced by the prooxidant mutagen dioxydine in bone marrow cellsin vivo is significantly higher in 5–6-month-old MRL/1 mice than in 1–2-month-old mice. It is suggested that these effects are more pronounced in 5–6-month-old animals due to progressive development of rheumatic pathology in this mouse strain. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 1, pp. 22–25, January, 1997 |
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| Keywords: | MRL/1 mice autoimmune pathology chemiluminescence chromosome aberrations dioxydine |
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