Synthesis and Antiulcer Activity Studies of 2-(1��-Iminothioimido Substituted)-1��-Substituted Phenylbenzoic acids

Certain 2-(1''-iminothioimido substituted)-1''-substituted phenybenzoic acids (P_1-9) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A_1-3) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was evaluated using reduction in total acidity, free acidity and ulcer index as parameters. Compounds P₃, P₆, P₇ and P₉(100 mg/kg) showed significant (P< 0.001) antiulcer action compared to control and omeprazole (40 mg/kg).