High Performance Thin Layer Chromatographic Method for Simultaneous Estimation of Ibuprofen and Pseudoephedrine Hydrochloride |
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| Authors: | S. S. Chitlange D. M. Sakarkar S. B. Wankhede S. G. Wadodkar |
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| Affiliation: | Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018, India;1S. N. Institute of Pharmacy, Pusad-445 204, India;2Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur-441 002, India |
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| Abstract: | High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F254 plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydrochloride was found to be 99.56% and 98.77%, respectively. Percent recovery for both the drugs was found in the range of 98.27% to 100.91%, respectively. |
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| Keywords: | Ibuprofen pseudoephedrine hydrochloride HPTLC t-butanol ethyl acetate glacial acetic acid water |
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