Estimation of active cortical current source regions using a vector representation scanning approach. |
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Authors: | Anthony L Ricamato Yasin Y Dhaher Julius P A Dewald |
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Affiliation: | Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Northwestern University, Chicago, Illinois 60185, USA. tony@developmentalinnovations.com |
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Abstract: | The objective of this article is to present a framework for cortical current source reconstruction that extracts a center and magnitude of electrical brain activity from EEG signals. High-resolution EEG recordings, a subject-specific MRI-based electromagnetic boundary element method (BEM) model, and a channel reduction technique are used. This new geometric measure combines the magnitude and spatial location of electrical brain activity of each of the identified subsets of channels into a three-dimensional resultant vector. The combination of the two approaches constitutes a source reconstruction scanning technique that provides a real-time estimation of cortical centers that can be tracked over time. Simulations demonstrate that the ability of this method to find the best-fit cortical location is more robust both in terms of accuracy and precision than traditional approaches for single-source conditions. Experimental validation demonstrates its ability to localize and separate cortical activity in plausible sites for two different motor tasks. Finally, this method provides a statistical measure to compare electrical brain activity associated with different motor tasks. |
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