Uneventful splenectomy and cholecystectomy in a patient treated with anti-interleukin-6 receptor antibody therapy |
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Authors: | Morihiko Ishizaki Tetsuro Sasada Akane Kunitomi Yoshiteru Konaka Masato Yagita Shutaro Gunji Michiyuki Kanai Norihiro Nishimoto Arimichi Takabayashi |
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Affiliation: | (1) Department of Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan;(2) Division of Hematology and Rheumatology, Department of Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan;(3) Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan |
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Abstract: | Introduction Interleukin-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune responses, acute phase reactions, and hematopoiesis. In rodent models, IL-6 has been suggested to be one of the essential mediators for optimal acute phase responses to infection and tissue damage. However, in humans, the roles of IL-6 in acute phase responses after surgery remain poorly understood. Case report We present the first case report of successful splenectomy and cholecystectomy in a severe autoimmune-associated hemolytic anemia patient during treatment with a humanized anti-IL-6 receptor antibody. Discussion This unique case suggests that IL-6 is not an essential cytokine to safely perform surgical intervention and to prevent postoperative complications and that surgical intervention may not be contraindicated but can be selected as a therapeutic modality in patients treated with anti-IL-6 receptor antibody therapy. |
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Keywords: | Interleukin-6 Anti-interleukin-6 receptor antibody Autoimmune associated hemolytic anemia Splenectomy Cholecystectomy |
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