| 国产乙酰消炎痛的药理研究 |
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| 引用本文： | 张远,陆迎春,楼雅卿,曹玮. 国产乙酰消炎痛的药理研究[J]. 中国药理学通报, 1987, 0(4) |
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| 作者姓名： | 张远 陆迎春 楼雅卿 曹玮 |
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| 作者单位： | 北京医科大学药理教研室(张远，陆迎春，楼雅卿)，中医研究院骨伤科所药理室(曹玮) |
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| 摘 要： | 乙酰消炎痛为国内新合成的非甾体类解热镇痛药消炎痛的衍生物,对小鼠腹腔毛细血管渗透性增加和耳廓炎症、角叉菜胶性大鼠足肿胀及棉球肉芽肿均有明显的抑制作用。能延长辐射热诱发大鼠疼痛的潜伏期,抑制醋酸所致小鼠的扭体反应。对发热大鼠有降温作用,抑制胶原诱导的血小板聚集,对胃粘膜有损伤作用。
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| 关 键 词： | 乙酰消炎痛 抗炎作用 镇痛解热 血小板聚集 |
ANTIINFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF ACEMETACIN |
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| Zhang Yuan.Cao Wei , Lu Yingchun et al. ANTIINFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF ACEMETACIN[J]. Chinese Pharmacological Bulletin, 1987, 0(4) |
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| Authors: | Zhang Yuan.Cao Wei & Lu Yingchun et al |
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| Abstract: | Acemetacin ( ACM ) , a synthetic non-steroid antipyretic analgesics, was produced in China. ACM lOmg/kg ig markedly inhibited the increased vascular permeability induced by 0.7% HAc and the swelling of ear induced by croton oil in mice, ACM 20mg/kg ig inhibited the edema of the rat paw caused by carrageenin and the proliferation of granuloma caused by cotton pellet,ACM 40mg/kg it; prolonged the potential time induced by radiant heat in rats and reduced the tempreture of feverish rats. It inhibited the mouse writhing caused by HAc. In addition, ACM showed an inhibitory effect on platelet aggregation induced -with collgen. It is suggested that ACM induced the stomach ulcers |
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| Keywords: | Acemetacin Antiinflammatory Antipyretic Analg- esic - Platelet aggregation |
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