产程中应用间苯三酚、安定、杜冷丁改善分娩的效果比较

目的]探讨间苯三酚、安定、杜冷丁在产程中的应用效果.方法]选择产程中宫颈水肿或质韧初产妇280例,潜伏期组（ n =90）予静脉推注间苯三酚80 mg（ n =30）或安定10 mg（ n =30）,或予肌注杜冷丁100 mg（ n =30）;加速期组（ n =60）予静推间苯三酚80 mg（ n =30）或安定10 mg（ n =30）;活跃期（中晚期组）（ n =45）予静推间苯三酚80 mg（ n =45）,产程各阶段均以同期拒绝宫颈处理设为对照（ n =30,30,25）,比较各组间疼痛、产程时间和并发症发生率等指标的变化.结果]潜伏期使用安定及杜冷丁病例中度疼痛以下所占比例较高（ P 〈0.05）.三种药物分别应用后2 h宫口开大均较明显,第一产程缩短（ P 〈0.05）,剖宫产、宫颈裂伤率等下降（ P 〈0.05）.加速期使用间苯三酚或安定,活跃期（中晚期）使用间苯三酚亦有同样效果.结论]三种药物在缩短产程、降低并发症等方面均具有明显效果,后两者因改善精神状态等优点,在潜伏期、活跃期早期更具优势,而间苯三酚因其安全性在活跃期更具使用价值.

Comparison of the Effects of Phloroglucinol, Diazepam or Pethidine During Delivery

Objective] To explore the effect of phlorogtucinol, diazepam or pethidine during delivery. Methods]Totally 280 primipara with cervix edema or hard texture were selected. The incubative stage group （ n =90） was injected intravenously with 80mg phloroglucinol（ n= 30） or 10mg diazepam（ n =30） or intramuscularly with 100mg pethidine（ n = 30）. The accelerated phage group（ n = 60） was given intravenously with 80mg phloroglucinol（ n =30） or 10mg diazepam（ n =30）. The middle and later active phase group（ n = 45） was given intravenously with 80mg phloroglucinol. No cervix treatment was given in the control group（ n =30,30,25, respectively） at the same time. Pain level, labor time and complications were compared among groups. Results] After the administration of diazepam or pethidine in the incubative stage, the pain was medium or mild（ P 〈0.05）. Two hours after the administration of three drugs, uterus ostium was enlarged significantly and the first stage of the labor was shortened（ P 〈0.05）, and the incidence of cesarean section and cervical laceration decreased（ P 〈0.05）. Phloroglucin or diazepam in the accelerated phage had the same effect as phloroglucin in the middle and later active phage. Conclusion]All the three drugs are effective in shortening the birth process and decreasing the complications. The later drugs diazepam and pethidine have the advantages such as the improvement of mental status, so they are predominant in the early stage of the incubative phase and active phase. Phloroglucin is useful in the active phage because of its safety.