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| 羟丙基-β-环糊精对依诺沙星角膜透过性的影响 | |
| 引用本文： | 刘志东,郭宏,李佳玮,丁平田,潘卫三. 羟丙基-β-环糊精对依诺沙星角膜透过性的影响[J]. 沈阳药科大学学报, 2004, 21(4): 250-252,256 |
| 作者姓名： | 刘志东 郭宏 李佳玮 丁平田 潘卫三 |
| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016 2. 佳木斯大学化学与药学院,黑龙江,佳木斯,140007 3. 沈阳药科大学制药工程学院,辽宁,沈阳,110016 |
| 摘 要： | 目的研究羟丙 β 环糊精 (HP β CD)对依诺沙星 (enoxacin ,ENX)角膜透过性的影响。 方法采用体外扩散实验考察在不同浓度HP β CD条件下ENX的离体兔眼角膜透过性。 结果 13、2 6和39mmol·L-1HP β CD组的表观渗透系数与对照组相比显著性增加 (P <0 0 1) ,2 6mmol·L-1HP β CD使得ENX的表观渗透系数达到最大 ,是对照组的 3 5 8倍 ;5 2和78mmol·L-1HP β CD组表观渗透系数与对照组相比没有显著性差异 (P >0 0 5 )。结论HP β CD浓度与ENX的表观渗透系数之间没有线性关系。 |
| 关 键 词： | 依诺沙星 羟丙基-β-环糊精 角膜透过性 |
| 文章编号： | 1006-2858(2004)04-0250-03 |
Effect of HP-β-CD on the permeability of enoxacin across the isolated rabbit''''s cornea |
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| LIU Zhi-dong,GUO Hong,LI Jia-wei,DING Ping-tian,PAN Wei-san. Effect of HP-β-CD on the permeability of enoxacin across the isolated rabbit''''s cornea[J]. Journal of Shenyang Pharmaceutical University, 2004, 21(4): 250-252,256 | |
| Authors: | LIU Zhi-dong GUO Hong LI Jia-wei DING Ping-tian PAN Wei-san |
| Affiliation: | LIU Zhi-dong1,GUO Hong2,LI Jia-wei3,DING Ping-tian1,PAN Wei-san1 |
| Abstract: | Objective To study the effect of HP-β-CD on the transcorneal permeability of enoxacin(ENX).Methods The permeability of a ENX across isolated rabbit′s cornea was measured using the in vitro method under HP-β-CD with different concentrations.Results 13,26 and 39 mmol·L -1 HP-β-CD showed more significantly promoting activity than the control.The largest value of the apparent permeation coefficient could be obtained at 26 mmol·L -1 HP-β-CD level which was 3.58 times more than that of the control.However,52 and 78 mmol·L -1 HP-β-CD showed no significant influence on the permeation coefficient.Conclusion There was lack of linearity between HP-β-CD and the apparent permeation coefficient of ENX. |
| Keywords: | enoxacin HP-β-CD transcorneal permeability |
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