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喉癌组织基膜和树突状细胞的检测
引用本文:胡孙宏,费青云,文三立,李德坚. 喉癌组织基膜和树突状细胞的检测[J]. 临床耳鼻咽喉头颈外科杂志, 1998, 12(7): 298-301
作者姓名:胡孙宏  费青云  文三立  李德坚
作者单位:1. 杭州,浙江医科大学附属邵逸夫医院耳鼻咽喉科,310016
2. 浙江湖州第二人民医院耳鼻咽喉科
3. 江西医学院第一附属医院耳鼻咽喉科
摘    要:为探讨喉癌组织基膜和树突状细胞的临床意义,采用免疫组织化学方法以抗层粘连蛋白、抗Ⅳ胶原、抗S-100蛋白抗体,标记68例喉癌患者癌组织与21例非喉癌组织基膜和DC。

关 键 词:喉肿瘤 组织基膜 树突状细胞 免疫组化 预后

The detection of basement membrane and dendritic cells in laryngeal carcinoma
Hu Sunhong ,Fei Qingyun, Wen Sanli, et al. The detection of basement membrane and dendritic cells in laryngeal carcinoma[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 1998, 12(7): 298-301
Authors:Hu Sunhong   Fei Qingyun   Wen Sanli   et al
Affiliation:Department of Otolaryngology, Sir Run Run Show Hospital, Zhejiang Medical University, Hangzhou 310016.
Abstract:The state of basement membrane(BM) and dendritic cells(DC) were observed by immunohistochemical methods with the use of anti-laminin antibody, anti-type IV collagen antibody, anti-S-100 protein antibody in 68 cases of laryngeal carcinoma and 21 cases of non-cancer laryngeal tissues. The results showed that among 68 patients with laryngeal carcinoma 39 cases had discontinuous BM. A continuous, linear BM was found mostly in normal larynx, atypia hyperplasia and papilloma, only 3 cases had discontinuous BM. 43 positive DC were detected in 68 cases of laryngeal carcinoma. There were rarely positive DC in non-cancer laryngeal tissues. The poorer the differentiation of carcinoma, the more the discontinuous BM and the lesser the number of DC. The discontinuous BM and DC(-) were seen more in advanced stages of carcinoma. The five-year survival rate in patients with continuous BM was significantly higher than that in patients with discontinuous BM, the five-year survival rate in patients with DC positive was also higher than that in patients with DC negative; the survival rate was highest in patients with continuous BM and DC positive. Our results indicated that the detection of the state of BM and dendritic cells were of value to the prognostic analysis in patients with laryngeal carcinoma.
Keywords:Laryngeal neoplasms Basement membrane Dendritic cell Immunologic technics
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