Type II estrogen binding sites (EBS) in intracranial tumors |
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| Authors: | A Capelli M Piantelli A Rinelli E Macri R Ricci L M Larocca M Scerrati R Roselli M Iacoangeli F O Ranelletti |
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| Institution: | Istituti di Anatomia Patologica, Università Cattolica del S. Cuore, Roma, Italy. |
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| Abstract: | Four meningiomas and six neuroepithelial tumors were assayed for the presence of estrogen receptors (ER), type II estrogen binding sites (EBS) and progesterone receptors (PgR). ER were detected in 7 out of 10 cases with levels ranging between 2.5 and 20.7 fmoles/mg of cytosolic protein. On the contrary, PgR were found in all samples (10 cases) and their levels ranged between 8.8 and 130.6 fmoles/mg of cytosolic protein. All tumor samples expressed appreciable amounts of type II EBS ranging between 452 and 2320 fmoles/mg of protein. Although the precise functional role of type II EBS is still unknown, their presence may reflect an hormonal sensitivity of these tumors. |
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