Forum Aminophylline reversal of diazepam sedation |
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Authors: | S. Arvidsson,MD,Consultant ,D. Niemand,MD,Consultant ,S. Martinell,MD,Consultant ,B. Ekströ m-Jodal,MD,Consultant |
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Affiliation: | Department of Anasthesiology, Östra Sjukhuset, 416 85 Göteborg Sweden |
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Abstract: | A double-blind randomised study was performed to investigate whether aminophylline reversed the sedative effect of diazepam. Thirty-two patients undergoing genito-urinary surgery with spinal or topical anaesthesia were given diazepam to maintain a state of deep sedation. Postoperatively patients received either aminophylline (60-120 mg) or physiological saline intravenously. The aminophylline group showed a rapid reversal of sedation, which persisted throughout the observation period of 2 hours. No such effect was seen in the patients who received saline and the difference was still obvious after 2 hours. It is concluded that aminophylline is a potent antagonist to the sedative effect of diazepam. |
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Keywords: | Hypnotics benzodiazepines, diazepam Pharmacology aminophylline |
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